Design, Synthesis, and Characterization of (2-Alkyl/aryl-3H-imidazo[2,1-c][1,2,4]triazol-3-yl)(aryl)methanone
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DOI: 10.1002/jhet.3009
Abstract: The important therapeutic properties of imidazole-related drugs have encouraged the medicinal chemists to synthesize and test a large number of novel molecules. In this investigation, it was of interest to synthesize (2-alkyl/aryl-3H-imidazo[2,1-c][1,2,4]triazol-3-yl)(aryl)methanone by short reaction… read more here.
Keywords: triazol aryl; aryl imidazo; alkyl aryl; aryl methanone ... See more keywords
Cyclic (Alkyl)- and (Aryl)-(amino)carbene Coinage Metal Complexes and Their Applications.
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DOI: 10.1021/acs.chemrev.0c00043
Abstract: Cyclic (alkyl)- and (aryl)-(amino)carbenes (CAACs and CAArCs) are stronger σ-donors and π-acceptors than imidazol-2-ylidenes and imidazolidin-2-ylidenes, the well-known N-heterocyclic carbenes (NHCs). Consequently, they form strong bonds with coinage metals and stabilize both low and high… read more here.
Keywords: aryl amino; coinage metal; coinage; alkyl aryl ... See more keywords
Structure–Reactivity Studies, Characterization, and Transformation of Intermediates by Lithium Chloride in the Direct Insertion of Alkyl and Aryl Iodides to Metallic Zinc Powder
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DOI: 10.1021/acs.organomet.6b00910
Abstract: Employment of fluorophore-tagged alkyl and aryl iodides permitted detection of persistent surface intermediates during their direct insertion to commercially available zinc powder. The sensitivity of this subensemble microscopy technique enabled structure–reactivity studies in the formation… read more here.
Keywords: direct insertion; zinc; aryl iodides; lithium chloride ... See more keywords
Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective Protonation of ( E)-α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated Esters.
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DOI: 10.1021/acs.orglett.8b02527
Abstract: A tandem Cu(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective protonation of ( E)-α-trialkylsilyl-β-alkyl(aryl)-α,β-unsaturated esters afforded the saturated products with d.r. values of >20:1 favoring the anti-diastereomer in modest to excellent isolated yields. read more here.
Keywords: diastereoselective protonation; conjugate addition; catalyzed conjugate; trialkylsilyl alkyl ... See more keywords
Pd-Catalyzed Allylic Alkylation of gem-Alkyl,Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers
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DOI: 10.1021/acscatal.7b04313
Abstract: (E)-gem-Alkyl,aryl-disubstituted allyl carbonates can react with ketones under Pd catalysis using a commercially available NHC ligand by suppressing the β-H elimination. Ketones with α-tertiary, β-quaternary carbon stereocenters were produced in high yields with high regio-… read more here.
Keywords: aryl disubstituted; tertiary quaternary; disubstituted allyl; quaternary carbon ... See more keywords
para-Selective hydroxylation of alkyl aryl ethers.
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DOI: 10.1039/d1cc06210g
Abstract: para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile… read more here.
Keywords: aryl ethers; hydroxylation alkyl; para selective; selective hydroxylation ... See more keywords
Carbodiimides as Acid Scavengers in Aluminum Triiodide Induced Cleavage of Alkyl Aryl Ethers
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DOI: 10.1055/s-0036-1588755
Abstract: A practical procedure for the cleavage of alkyl aryl ethers containing labile functional groups has been developed using aluminum triiodide as the ether cleaving reagent. Carbodiimides, typically used as dehydration reagents for the coupling of… read more here.
Keywords: aryl ethers; alkyl aryl; cleavage alkyl; aluminum triiodide ... See more keywords
Iron-catalyzed aerobic oxidation of (Alkyl)(aryl)azinylmethanes
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DOI: 10.1055/s-0036-1589014
Abstract: An iron-catalyzed aerobic oxidation of (alkyl)(aryl)azinylmethanes has been developed leading to tertiary alcohols in moderate to good yields. Hock rearrangement was identified as a major side reaction leading to a complex mixture of undesired products.… read more here.
Keywords: iron catalyzed; aryl azinylmethanes; oxidation alkyl; aerobic oxidation ... See more keywords
Hydrogen-Bond-Promoted Friedel–Crafts Reaction of Secondary Propargylic Fluorides: Preparation of 1-Alkyl-1-aryl-2-alkynes
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DOI: 10.1055/s-0036-1589057
Abstract: We report that aromatic propargylation is achievable with secondary propargylic fluorides, thus affording 1-alkyl-1-aryl-2-alkynes. In the present case, hydrogen bonding is responsible for the activation of the C–F bond. A large excess of arene nucleophile… read more here.
Keywords: secondary propargylic; hydrogen bond; aryl alkynes; propargylic fluorides ... See more keywords
Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3
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DOI: 10.1080/14756366.2019.1705294
Abstract: Abstract 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives were designed and synthesised as selective inhibitors of JNK3, a target for the treatment of neurodegenerative diseases. Following previous studies, we have designed JNK3 inhibitors to reduce the molecular weight and successfully… read more here.
Keywords: pyrazole derivatives; pyrimidyl pyrazole; aryl pyrimidyl; alkyl aryl ... See more keywords
Carbene reactivity from alkyl and aryl aldehydes
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DOI: 10.1126/science.abo6443
Abstract: Carbenes are highly enabling reactive intermediates that facilitate a diverse range of otherwise inaccessible chemistry, including small-ring formation and insertion into strong σ bonds. To access such valuable reactivity, reagents with high entropic or enthalpic… read more here.
Keywords: reactivity alkyl; carbene reactivity; reactivity; alkyl aryl ... See more keywords