Synthesis of Secondary Trifluoromethylated Alkyl Bromides Using 2-Bromo-3,3,3-trifluoropropene as a Radical Acceptor.
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DOI: 10.1021/acs.orglett.2c00425
Abstract: Herein, the first example using commercially available 2-bromo-3,3,3-trifluoropropene (BTP) as a radical acceptor has been reported. Taking advantage of this strategy, a wide range of secondary trifluoromethylated alkyl bromides were synthesized in good to excellent… read more here.
Keywords: bromo trifluoropropene; alkyl bromides; secondary trifluoromethylated; trifluoromethylated alkyl ... See more keywords
Nickel-Catalyzed Reductive Coupling of γ-Metalated Ketones with Unactivated Alkyl Bromides.
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DOI: 10.1021/acs.orglett.2c01390
Abstract: A nickel-catalyzed reductive cross-coupling reaction of aryl cyclopropyl ketones with easily accessible unactivated alkyl bromides to access aryl alkyl ketones has been developed. This strategy facilitates access to various of γ-alkyl-substituted ketones via ring opening… read more here.
Keywords: unactivated alkyl; nickel catalyzed; reductive coupling; alkyl bromides ... See more keywords
Oxy-Alkylation of Allylamines with Unactivated Alkyl Bromides and CO2 via Visible-Light-Driven Palladium Catalysis.
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DOI: 10.1021/acs.orglett.8b01079
Abstract: A selective oxy-alkylation of allylamines with unactivated alkyl bromides and CO2 via visible-light-driven palladium catalysis is reported. The commercially available Pd(PPh3)4 is used as the sole catalyst in this three-component reaction. A variety of tertiary,… read more here.
Keywords: unactivated alkyl; allylamines unactivated; bromides co2; alkylation allylamines ... See more keywords
Ni-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with gem-difluoroalkenes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04162h
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc04162h
Abstract: A migratory fluoro-alkenylation of unactivated alkyl bromides is reported; the reaction is enabled by fluorine effects and involves an alkyl nickel chain-walking mechanism. read more here.
Keywords: unactivated alkyl; alkenylation unactivated; alkyl bromides; fluoro alkenylation ... See more keywords
Cu-Catalyzed cyanoalkylation of electron-deficient alkenes with unactivated alkyl bromides.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04432a
Abstract: We here report the photoinduced Cu-catalyzed cyanoalkylation of electron-deficient alkenes by using alkyl bromides as alkylation reagents. In the reactions, 1°, 2°, and 3° unactivated alkyl bromides with various sensitive functional groups were well tolerated… read more here.
Keywords: unactivated alkyl; alkyl bromides; cyanoalkylation electron; deficient alkenes ... See more keywords
Enantiospecific on-water bromination: a mild and efficient protocol for the preparation of alkyl bromides
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DOI: 10.1039/d0gc02855j
Abstract: Herein we report the first example of an on-water enantiospecific synthesis of alkyl bromides. This procedure allowed the conversion of secondary activated alkyl sulphides to benzylic alkyl bromides, which were obtained in high yields and… read more here.
Keywords: water; alkyl bromides; bromination mild; enantiospecific water ... See more keywords
Preparation of thioamides from alkyl bromides, nitriles, and hydrogen sulfide through a thio-Ritter-type reaction.
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DOI: 10.1039/d2cc04210j
Abstract: A novel thio-Ritter-type reaction of alkyl bromides, nitriles, and hydrogen sulfide has been explored, providing a straightforward approach toward functionally important thioamides. This transformation features a broad substrate scope, operational simplicity, use of available feedstock… read more here.
Keywords: type reaction; reaction; alkyl bromides; thio ritter ... See more keywords
Copper-Catalyzed Intermolecular Carboesterification of Unactivated Aliphatic Alkenes with α-Carbonyl Alkyl Bromides via a SET Process: Efficient Synthesis of γ-Lactones
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DOI: 10.1039/d3qo00096f
Abstract: A novel and efficient copper-catalyzed carboesterification of unactivated alkenes with α-carbonyl alkyl bromides for the syn-thesis of γ-lactones derivatives has been developed. With the assistance of a removable bidentate 8-aminoquinoline... read more here.
Keywords: carboesterification unactivated; alkyl bromides; carbonyl alkyl; copper catalyzed ... See more keywords