Copper-catalyzed cross-coupling reactions of non-activated primary, secondary or tertiary alkyl chlorides with phenylmagnesium bromide
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2016.12.013
Abstract: Abstract Efficient copper-catalyzed cross-coupling reactions of non-activated alkyl chlorides, including primary, secondary, and tertiary alkyl chlorides, with phenyl Grignard reagents were achieved. Preparation of phenylmagnesium bromide in 2-methyltetrahydrofuran is critical for the success of the… read more here.
Keywords: alkyl chlorides; non activated; cross coupling; primary secondary ... See more keywords
Cross-Electrophile Coupling of Unactivated Alkyl Chlorides.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c04812
Abstract: Alkyl chlorides are bench-stable chemical feedstocks that remain among the most underutilized electrophile classes in transition metal catalysis. Overcoming intrinsic limitations of C(sp3)-Cl bond activation, we report the development of a novel organosilane reagent that… read more here.
Keywords: alkyl; alkyl chlorides; unactivated alkyl; cross electrophile ... See more keywords
Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides
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DOI: 10.1038/s41467-021-23255-0
Abstract: Development of practical deuteration reactions is highly valuable for organic synthesis, analytic chemistry and pharmaceutic chemistry. Deuterodehalogenation of organic chlorides tends to be an attractive strategy but remains a challenging task. We here develop a… read more here.
Keywords: alkyl chlorides; deuterodehalogenation aryl; chemistry; organophotocatalytic selective ... See more keywords
Photocatalytic activation of alkyl chlorides by assembly-promoted single electron transfer in microheterogeneous solutions
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DOI: 10.1038/s41929-019-0369-5
Abstract: Photoredox catalysis has developed into a powerful tool for the synthesis of organic compounds with diverse structures. However, stable carbon–chloride bonds remain beyond the energetic limits of the outer-sphere photoreductive activation. Here, we demonstrate that… read more here.
Keywords: alkyl chlorides; single electron; assembly promoted; electron transfer ... See more keywords
Rh-catalyzed alkoxycarbonylation of unactivated alkyl chlorides
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DOI: 10.1039/d2sc04103k
Abstract: A general rhodium-catalyzed selective carbonylative coupling of unactivated alkyl chlorides with aliphatic alcohols or phenols to the corresponding esters is presented for the first time. Crucial for this transformation is the addition of sodium iodide,… read more here.
Keywords: unactivated alkyl; alkyl chlorides; catalyzed alkoxycarbonylation; alkoxycarbonylation unactivated ... See more keywords
Nickel catalyzed three-component sulfonylation of non-activated alkyl chlorides.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01447a
Abstract: We describe a nickel-catalyzed three-component sulfonylation of readily available non-activated alkyl chlorides. A wide range of alkyl aryl sulfones can be synthesized from alkyl chlorides, aryl boronic acids, and potassium metabisulfite, a cheap, efficient, and… read more here.
Keywords: alkyl chlorides; nickel catalyzed; component sulfonylation; catalyzed three ... See more keywords
A New Protocol for Catalytic Reduction of Alkyl Chlorides Using an Iridium/Bis(benzimidazol-2′-yl)pyridine Catalyst and Triethylsilane
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DOI: 10.1055/a-1527-4526
Abstract: The reduction of alkyl chlorides using triethylsilane is investigated. Primary, secondary, tertiary, and benzylic C–Cl bonds are effectively converted into C–H bonds using an [IrCl(cod)]2/2,6-bis(benzimidazol-2′-yl)pyridine catalyst system. This catalyst system is quite simple since the… read more here.
Keywords: catalyst; reduction alkyl; benzimidazol pyridine; bis benzimidazol ... See more keywords