Regiodivergent Synthesis Utilizing Alkyl Hex-5-en-2-ynoates and 3-Homoacyl Coumarins: Phenol-Mediated Controllable Phosphine-Catalyzed Michael and 1,7-Umpolung Addition.
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DOI: 10.1021/acs.orglett.5c04035
Abstract: We disclose a first example of regiodivergent addition between alkyl hex-5-en-2-ynoates and 3-homoacyl coumarins under phosphine catalysis, in which phenol serves as a decisive additive. This study demonstrates a phenol-mediated switchable pathway between Michael addition… read more here.
Keywords: michael; ynoates homoacyl; alkyl hex; hex ynoates ... See more keywords