Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.
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DOI: 10.1016/j.bioorg.2019.103071
Abstract: A novel series of 4-pyridylpiperazine derivatives with varying alkyl linker length and eastern part substituents proved to be potent histamine H3 receptor (hH3R) ligands in the nanomolar concentration range. While paying attention to their alkyl… read more here.
Keywords: affinity; alkyl linker; histamine receptor; methylene ... See more keywords