Understanding the Gas Phase Chemistry of Alkanes with First-Principles Calculations
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DOI: 10.1021/acs.jced.7b00992
Abstract: Alkyl radicals are key intermediates in multiple industrially important reactions, including the dehydrogenation of alkanes. Because of their diverse chemistry, alkyl radicals form various products via a number of competing reactions in the gas phase.… read more here.
Keywords: alkene formation; gas phase; alkyl radicals; chemistry ... See more keywords
Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00455
Abstract: Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues.… read more here.
Keywords: elastase; elastase activatable; neutrophil elastase; alkyl radicals ... See more keywords
Enantioselective Addition of Remote Alkyl Radicals to Double Bonds by Photocatalytic Proton-Coupled Electron Transfer (PCET) Deconstruction of Unstrained Cycloalkanols.
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DOI: 10.1021/acs.orglett.2c00662
Abstract: Herein, we report the enantioselective addition of remote alkyl radicals, generated from the ring opening of unstrained cycloalkanols by a proton-coupled electron transfer (PCET) process, to 2-acyl imidazoles previously coordinated to a rhodium-based chiral Lewis… read more here.
Keywords: alkyl radicals; addition remote; remote alkyl; enantioselective addition ... See more keywords
Synthesizing Complex Quaternary Carbons by the Sequence-Regulated Additions of tert-Alkyl Radicals to Two Different Olefins.
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DOI: 10.1021/acs.orglett.3c00812
Abstract: We report the sequence-regulated radical additions of tert-alkyl radicals to two different olefins controlled by a Cu catalyst, which we term the "atom-transfer radical addition-substitution" reaction. The reactions of α-bromocarbonyl compounds, such as tert-alkyl radical… read more here.
Keywords: additions tert; radicals two; sequence regulated; alkyl radicals ... See more keywords
Redox-active alkylsulfones as precursors for alkyl radicals under photoredox catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00163b
Abstract: A method for generating alkyl radicals using visible-light photoredox catalysis is described. This procedure was found to present an efficient means to access a diverse collection of 1°, 2°, and 3° alkyl radicals through the… read more here.
Keywords: active alkylsulfones; alkylsulfones precursors; redox active; photoredox catalysis ... See more keywords