Reconstructed chitosan with alkylamine for enhanced gene delivery by promoting endosomal escape.
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DOI: 10.1016/j.carbpol.2019.115339
Abstract: Poor buffering capacity of chitosan (CS) results in insufficient intracellular gene release which poses the major barrier in gene delivery. Herein, we reconstructed pristine CS with propylamine (PA), (diethylamino) propylamine (DEAPA), and N, N-dimethyl- dipropylenetriamine… read more here.
Keywords: alkylamine; delivery; gene delivery; gene ... See more keywords
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
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DOI: 10.1038/s41467-024-49739-3
Abstract: Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently… read more here.
Keywords: degradation; alkylamine; protein degradation; targeted protein ... See more keywords