Reconstructed chitosan with alkylamine for enhanced gene delivery by promoting endosomal escape.
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DOI: 10.1016/j.carbpol.2019.115339
Abstract: Poor buffering capacity of chitosan (CS) results in insufficient intracellular gene release which poses the major barrier in gene delivery. Herein, we reconstructed pristine CS with propylamine (PA), (diethylamino) propylamine (DEAPA), and N, N-dimethyl- dipropylenetriamine… read more here.
Keywords: alkylamine; delivery; gene delivery; gene ... See more keywords