Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: a test of N-glycosylation methodologies on a lipophilic peroxide
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DOI: 10.1016/j.tet.2018.04.027
Abstract: Abstract 10-Alkylamino-artemisinins including artemiside and artemisone display enhanced activities against malaria. Earlier, dihydroartemisinin (DHA) TMS ether was converted by trimethylsilyl bromide into the 10-β-bromide that with amine nucleophiles provided the amino-artemisinins. In an attempt to… read more here.
Keywords: alkylamino; alkylamino artemisinins; optimization synthetic; artemiside artemisone ... See more keywords