LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "alkylating agent" as a keyword



L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease

Sign Up to like & get
recommendations! Published in 2017 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2017.01.007

Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.

Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords
Photo from archive.org

Hexyl triazabutadiene as a potent alkylating agent

Sign Up to like & get
recommendations! Published in 2017 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2017.05.056

Abstract: Abstract Alkyl diazonium ions are among the most reactive alkylating agents in the synthetic chemists’ arsenal. That said, there are precious few methods by which one can selectively and safely utilize this chemistry. Herein, we… read more here.

Keywords: chemistry; hexyl triazabutadiene; alkylating agent; triazabutadiene potent ... See more keywords

The Toxicity of Dimethyl Sulfoxide Combined with the Alkylating Agent MNU on Mice: Focusing on Mortality and Activity Impairment

Sign Up to like & get
recommendations! Published in 2025 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s521506

Abstract: Objective Dimethyl sulfoxide (DMSO) is known to enhance the absorption of chemicals. This study investigated the effects of DMSO in combination with the alkylating agent, N-methyl-N-nitrosourea (MNU), on the activity and mortality of mice, providing… read more here.

Keywords: mice; mortality; mnu; alkylating agent ... See more keywords

In Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review

Sign Up to like & get
recommendations! Published in 2025 at "Antioxidants"

DOI: 10.3390/antiox14060712

Abstract: Alkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological changes, highlighting… read more here.

Keywords: induced pulmonary; review; agent; pulmonary toxicity ... See more keywords