Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800235
Abstract: Drugs that covalently modify DNA are components of most chemotherapy regimens, often serving as first‐line treatments. Classically, the reactivity and selectivity of DNA alkylating agents has been determined in vitro with short oligonucleotides. A statistically… read more here.
Keywords: agents rna; profiling nucleobase; alkylating agents; structure ... See more keywords
Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: preclinical and clinical data.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105976
Abstract: Seizures are relatively common in cancer patients, and co-administration of chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many cases. Nonetheless, clinically relevant interactions between chemotherapeutic drugs and AEDs are rarely summarized… read more here.
Keywords: interactions alkylating; alkylating agents; pharmacological interactions; relevant pharmacological ... See more keywords
Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.07.023
Abstract: Vesicants cause a multitude of cutaneous reactions like erythema, blisters and ulcerations. After exposure to sulfur mustard (SM) and related compounds, patients present dermal symptoms typically known for chemicals categorized as skin sensitizer (e.g. hypersensitivity… read more here.
Keywords: alkylating agents; sulfur mustard; accordance oecd; skin sensitizing ... See more keywords
HFIP Solvent Enables Alcohols To Act as Alkylating Agents in Stereoselective Heterocyclization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b02198
Abstract: A new method for the stereoselective synthesis of highly functionalized oxygen heterocycles using allyl or benzyl alcohols as alkylating agents is presented. The process is efficient and atom economic, generating water as the only stoichiometric… read more here.
Keywords: enables alcohols; hfip solvent; solvent enables; alkylating agents ... See more keywords
A ubiquitin-dependent signaling axis specific for ALKBH-mediated DNA dealkylation repair
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24484
Abstract: DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms… read more here.
Keywords: alkylating agents; ubiquitin dependent; damage; alkylation ... See more keywords
P–435 LH preserves oocyte-granulosa cell communication in mouse ovaries exposed to chemotherapy with alkylating agents
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab130.434
Abstract: Does Luteinizing Hormone (LH) protect the follicular endowment and growth by improving oocyte-granulosa cell (GC) communication of follicles exposed to chemotherapy at the primordial stage? LH treatment protects mouse primordial follicles against alkylating agents by… read more here.
Keywords: chemotherapy; oocyte granulosa; cht; alkylating agents ... See more keywords
Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz512
Abstract: Abstract Higher-ordered structure motifs of nucleic acids, such as the G-quadruplex (G-4), mismatched and bulge structures, are significant research targets because these structures are involved in genetic control and diseases. Selective alkylation of these higher-order… read more here.
Keywords: alkylating agents; nucleic acids; reactive type; higher ordered ... See more keywords
A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-0093
Abstract: The identified genetic markers harbor potential clinical utility in characterizing high-risk survivors and guiding intervention strategies including pretreatment patient counseling and use of fertility preservation services. Exposure to high doses of alkylating agents is associated… read more here.
Keywords: cancer survivors; novel locus; childhood cancer; cancer ... See more keywords
ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28193
Abstract: The antineoplastic activity of pre-transplant regimens in hematopoietic stem cell transplantation (HSCT) is a critical factor for acute myeloid leukemia (AML) patients. There is an urgent need to identify novel approaches without jeopardizing patient safety.… read more here.
Keywords: alkylating agents; acute myeloid; myeloid leukemia; cytotoxicity ... See more keywords
Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210811105344
Abstract: Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer diagnoses increased to 18.1 million in… read more here.
Keywords: agents road; alkylating agents; traversed changing; road less ... See more keywords
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Biomedicines"
DOI: 10.3390/biomedicines7030069
Abstract: The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor. GB affects 3.2 in 100,000 people… read more here.
Keywords: agents glioblastoma; temozolomide alkylating; alkylating agents; treatment ... See more keywords