Synergistic Copper‐Aminocatalysis for Direct Tertiary α‐Alkylation of Ketones with Electron‐Deficient Alkanes
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DOI: 10.1002/advs.202402255
Abstract: In this study, a novel approach for the tertiary α‐alkylation of ketones using alkanes with electron‐deficient C─H bonds is presented, employing a synergistic catalytic system combining inexpensive copper salts with aminocatalysis. This methodology addresses the… read more here.
Keywords: tertiary alkylation; alkylation ketones; electron deficient; copper ... See more keywords
Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible‐Light Induced Ring‐Opening Fragmentation.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600415
Abstract: A visible-light photoredox catalyzed ring-opening functionalization of tetrahydroisoquinolines with bisindole alkylation has been developed, which expedites a new vista for the synthesis of bis(indolyl)methane derivatives. The transformation comprises a series of cascade reactions, photoredox catalysis,… read more here.
Keywords: alkylation; indolyl methane; methane derivatives; bis indolyl ... See more keywords
Microwave‐Promoted Metal‐Free α‐Alkylation of Ketones with Cycloalkanes through Cross‐Coupling of C(sp3)−H Bonds
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DOI: 10.1002/ajoc.201700256
Abstract: A MWI-promoted α-alkylation of ketones by using cycloalkanes as the alkylating agents under metal-free conditions is presented. Mechanistically, this alkylation involves a TBP-initiated and MWI-assisted formation of the required cycloalkyl radical and the α-ketone carbon… read more here.
Keywords: coupling sp3; sp3 bonds; alkylation; metal free ... See more keywords
Bioorthogonal Metalloporphyrin‐Catalyzed Selective Methionine Alkylation in the Lanthipeptide Nisin
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DOI: 10.1002/cbic.201800493
Abstract: Bioorthogonal catalytic modification of ribosomally synthesized and post‐translationally modified peptides (RiPPs) is a promising approach to obtaining novel antimicrobial peptides with improved properties and/or activities. Here, we present the serendipitous discovery of a selective and… read more here.
Keywords: metalloporphyrin catalyzed; bioorthogonal metalloporphyrin; catalyzed selective; lanthipeptide nisin ... See more keywords
Transition‐Metal Catalyzed C−H Alkylation Using Epoxides as Alkylating Reagents
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DOI: 10.1002/cctc.202301764
Abstract: The alkylation of arenes is one of the most fundamental transformations in synthetic chemistry and the transition‐metal‐catalyzed direct C−H alkylation represents a straightforward and attractive approach from both atom and step‐economy perspectives. Epoxides, the smallest… read more here.
Keywords: alkylating reagents; metal catalyzed; transition metal; transition ... See more keywords
Pincer–Ruthenium Catalyzed Selective α‐Alkylation of Nitriles
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DOI: 10.1002/cctc.202401744
Abstract: The catalytic α‐alkylation of benzyl nitriles with benzyl alcohols has been investigated with NNN pincer–ruthenium (Ru) complexes based on bis(imino)pyridine and 2,6‐bis(benzimidazole‐2‐yl)pyridine ligands. The complex [Cy2NNN(RuCl2(PPh3)] was found to be the most efficient in comparison… read more here.
Keywords: pincer ruthenium; ruthenium catalyzed; kcal mol; alkylation ... See more keywords
Visible Light‐Promoted Enantioselective Catalytic Alkylation of α‐Ketoamides with Hydrocarbons
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DOI: 10.1002/cctc.202402112
Abstract: Visible light‐mediated enantioselective alkylation of carbonyls with hydrocarbons provides beneficial access to the synthesis of chiral alcohols in terms of atom economy. Herein, we disclosed a direct asymmetric alkylation of α‐keto pyrazoleamides with hydrocarbons as… read more here.
Keywords: light promoted; promoted enantioselective; visible light; catalytic alkylation ... See more keywords
Asymmetric Radical Alkylation Enabled by Synergistic Photoredox Enamine Biocatalysis
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DOI: 10.1002/cctc.202501219
Abstract: Class I aldolases, a unique link among biochemistry, organic chemistry, and computational chemistry are powerful C─C bond‐forming enzymes in synthetic chemistry and industry because of their unparalleled selectivity, extensive substrate scope and scalability. However, the… read more here.
Keywords: chemistry; synergistic photoredox; asymmetric radical; alkylation ... See more keywords
Bifunctional Molybdenum Polyoxometalates for the Combined Hydrodeoxygenation and Alkylation of Lignin-Derived Model Phenolics.
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DOI: 10.1002/cssc.201700297
Abstract: Reductive catalytic fractionation of biomass has recently emerged as a powerful lignin extraction and depolymerization method to produce monomeric aromatic oxygenates in high yields. Here, bifunctional molybdenum-based polyoxometalates supported on titania (POM/TiO2 ) are shown… read more here.
Keywords: lignin derived; bifunctional molybdenum; alkylation; hydrodeoxygenation ... See more keywords
Ni-Catalyzed α-Alkylation of Unactivated Amides and Esters with Alcohols by Hydrogen Auto-Transfer Strategy.
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DOI: 10.1002/cssc.201801443
Abstract: A transition-metal-catalyzed borrowing hydrogen/hydrogen auto-transfer strategy allows the utilization of feedstock alcohols as an alkylating partner, which avoids the formation of stoichiometric salt waste and enables a direct and benign approach for the construction of… read more here.
Keywords: alkylation; auto transfer; hydrogen auto; transfer strategy ... See more keywords
Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols.
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DOI: 10.1002/cssc.202002830
Abstract: The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble… read more here.
Keywords: alkylation anilines; catalyzed direct; alkylation; anilines alcohols ... See more keywords