Direct radical alkylation and acylation of 2H-indazoles using substituted Hantzsch esters as radical reservoirs
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DOI: 10.1039/d0qo00507j
Abstract: A platform approach for the direct synthesis of 3-substituted 2H-indazole derivatives has been developed using a Ag(I)/Na2S2O8 system. This regioselective alkylation/acylation protocol operates under mild conditions, tolerates a wide range of structural moieties and delivers… read more here.
Keywords: radical alkylation; acylation indazoles; alkylation acylation; direct radical ... See more keywords