Diastereoselective C-alkylation of aldimines, derived from chiral α-carbon heteroatom-substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
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DOI: 10.1039/d3ra01397a
Abstract: The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and diastereoisomeric ratios. Stereocontrol is induced by the presence of a heteroatom in the… read more here.
Keywords: heteroatom; diastereoselective alkylation; alkylation aldimines; synthesis ... See more keywords