Direct Alkylation of 1-Azabicyclo[1.1.0]butanes.
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DOI: 10.1021/acs.orglett.9b00321
Abstract: The facile synthesis of functionalized azetidines has been an ongoing challenge. Here, we report a general method to directly alkylate 1-azabicyclo[1.1.0]butane (ABB) with organometal reagents in the presence of Cu(OTf)2 to rapidly prepare bis-functionalized azetidines.… read more here.
Keywords: alkylation azabicyclo; direct alkylation; azabicyclo butanes;