Intersections between transcription-coupled repair and alkylation damage reversal.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102663
Abstract: The response to DNA damage intersects with many other physiological processes in the cell, such as DNA replication, chromatin remodeling, and the cell cycle. Certain damaging lesions, such as UV-induced pyrimidine dimers, also strongly block… read more here.
Keywords: damage reversal; alkylation damage; damage; transcription coupled ... See more keywords
Versatile cell-based assay for measuring DNA alkylation damage and its repair
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DOI: 10.1038/s41598-021-97523-w
Abstract: DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repair pathway that… read more here.
Keywords: alkylation; alkylation damage; damage repair; dna ... See more keywords
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
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DOI: 10.1158/2159-8290.cd-21-0205
Abstract: RNF113A methylation by SMYD3 improves alkylation damage response and impairs small cell lung cancer sensitivity to alkylation-based chemotherapy. read more here.
Keywords: lung cancer; rnf113a methylation; alkylation damage; small cell ... See more keywords