Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis.
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DOI: 10.1021/acs.orglett.2c00697
Abstract: Herein, we report an on-DNA photoredox-mediated deaminative alkylation method for diversifying DNA-tagged acrylamide substrate with amine-derived radicals. The radicals can be conveniently generated from sterically hindered primary amines, and the deaminative alkylation can tolerate a… read more here.
Keywords: dna; photoredox deaminative; deaminative alkylation; dna encoded ... See more keywords