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   Articles with "alkylation indoles" as a keyword



Nickel‐Catalyzed Branch Selective C‐H Alkylation of Indoles and Azoles with Alkenes: An Additive‐ and Solvent‐Free Approach

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recommendations! Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202400376

Abstract: The development of sustainable protocols for the synthesis of alkylated heteroarenes is crucial owing to their widespread existence in medicinally relevant and bioactive natural products. Herein, we describe an efficient, additive‐ and solvent‐free approach for… read more here.

Keywords: additive solvent; chemistry; solvent free; alkylation ... See more keywords

Chiral phosphoric acid catalyzed aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters

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recommendations! Published in 2017 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2016.12.012

Abstract: Abstract A highly enantioselective aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters catalyzed by a chiral phosphoric acid has been developed, the corresponding α,α-disubstituted unnatural α-amino ester derivatives were obtained in moderate to high… read more here.

Keywords: crafts alkylation; cyclic aryl; indoles cyclic; alkylation indoles ... See more keywords
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MnBr2-Catalyzed Direct and Site-Selective Alkylation of Indoles and Benzo[h]quinoline.

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recommendations! Published in 2020 at "Organic letters"

DOI: 10.1021/acs.orglett.0c01398

Abstract: Manganese-catalyzed regioselective C-H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C-H functionalization, this protocol does not require a Grignard reagent base and employs a simple… read more here.

Keywords: benzo quinoline; mnbr2 catalyzed; alkylation indoles; indoles benzo ... See more keywords

Weak Chelation-Assisted C4-Selective Alkylation of Indoles with Cyclopropanols via Sequential C-H/C-C Bond Activation.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c02265

Abstract: A Rh-catalyzed weak chelation-guided C4-alkylation of indoles has been accomplished using cyclopropanols as an alkylating agent via the cascade C-H and C-C bond activation. The substrate scope, functional group tolerance, and late-stage mutation of drug… read more here.

Keywords: weak chelation; alkylation indoles; bond activation;

Co-Mabiq Flies Solo: Light-Driven Markovnikov-Selective C- and N-Alkylation of Indoles and Indazoles without a Cocatalyst.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c10930

Abstract: Indoles and indazoles are common moieties in pharmaceuticals and naturally occurring bioactive compounds. The development of light-driven methods using earth-abundant transition-metal catalysts offers an attractive route for functionalization of such compounds. Herein, we report a… read more here.

Keywords: indoles indazoles; alkylation; alkylation indoles; mabiq flies ... See more keywords
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Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water

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recommendations! Published in 2020 at "RSC Advances"

DOI: 10.1039/c9ra09227g

Abstract: A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium.… read more here.

Keywords: alkylation indoles; light mediated; visible light; light ... See more keywords

Fe(II)-Catalyzed Metal–Ligand Cooperative Approach for Selective C3 -Alkylation of Indoles

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recommendations! Published in 2024 at "Synlett"

DOI: 10.1055/a-2384-6655

Abstract: Herein, we report a straightforward approach for synthesizing C3 -alkylated indoles selectively via an iron-catalyzed alkylation of indoles using alcohols as the alkylating agents. A well-defined, air-stable, and easy-to-prepare Fe(II) catalyst of a redox-active tridentate… read more here.

Keywords: catalyzed metal; alkylation; alkylation indoles; ligand cooperative ... See more keywords

K2S2O8-Activated Friedel–Crafts Type Alkylation of Indoles with α-Amido Sulfones

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recommendations! Published in 2017 at "Synthesis"

DOI: 10.1055/s-0036-1589073

Abstract: A K 2 S 2 O 8 -activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by… read more here.

Keywords: alkylation indoles; amido sulfones; crafts type; alkylation ... See more keywords

Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines

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recommendations! Published in 2020 at "Catalysts"

DOI: 10.3390/catal10090971

Abstract: Over the course of the present studies, a series of optically pure phosphines functionalized by chiral aziridines was synthesized in reasonable/good chemical yields. Their catalytic activity was checked in the enantioselective Friedel–Crafts alkylation of indoles… read more here.

Keywords: crafts alkylation; alkylation indoles; asymmetric friedel; indoles catalyzed ... See more keywords