Chiral phosphoric acid catalyzed aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters
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DOI: 10.1016/j.tetlet.2016.12.012
Abstract: Abstract A highly enantioselective aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters catalyzed by a chiral phosphoric acid has been developed, the corresponding α,α-disubstituted unnatural α-amino ester derivatives were obtained in moderate to high… read more here.
Keywords: crafts alkylation; cyclic aryl; indoles cyclic; alkylation indoles ... See more keywords
MnBr2-Catalyzed Direct and Site-Selective Alkylation of Indoles and Benzo[h]quinoline.
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DOI: 10.1021/acs.orglett.0c01398
Abstract: Manganese-catalyzed regioselective C-H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C-H functionalization, this protocol does not require a Grignard reagent base and employs a simple… read more here.
Keywords: benzo quinoline; mnbr2 catalyzed; alkylation indoles; indoles benzo ... See more keywords
Weak Chelation-Assisted C4-Selective Alkylation of Indoles with Cyclopropanols via Sequential C-H/C-C Bond Activation.
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DOI: 10.1021/acs.orglett.2c02265
Abstract: A Rh-catalyzed weak chelation-guided C4-alkylation of indoles has been accomplished using cyclopropanols as an alkylating agent via the cascade C-H and C-C bond activation. The substrate scope, functional group tolerance, and late-stage mutation of drug… read more here.
Keywords: weak chelation; alkylation indoles; bond activation;
Co-Mabiq Flies Solo: Light-Driven Markovnikov-Selective C- and N-Alkylation of Indoles and Indazoles without a Cocatalyst.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10930
Abstract: Indoles and indazoles are common moieties in pharmaceuticals and naturally occurring bioactive compounds. The development of light-driven methods using earth-abundant transition-metal catalysts offers an attractive route for functionalization of such compounds. Herein, we report a… read more here.
Keywords: indoles indazoles; alkylation; alkylation indoles; mabiq flies ... See more keywords
Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water
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DOI: 10.1039/c9ra09227g
Abstract: A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium.… read more here.
Keywords: alkylation indoles; light mediated; visible light; light ... See more keywords
K2S2O8-Activated Friedel–Crafts Type Alkylation of Indoles with α-Amido Sulfones
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DOI: 10.1055/s-0036-1589073
Abstract: A K 2 S 2 O 8 -activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by… read more here.
Keywords: alkylation indoles; amido sulfones; crafts type; alkylation ... See more keywords
Asymmetric Friedel–Crafts Alkylation of Indoles Catalyzed by Chiral Aziridine-Phosphines
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DOI: 10.3390/catal10090971
Abstract: Over the course of the present studies, a series of optically pure phosphines functionalized by chiral aziridines was synthesized in reasonable/good chemical yields. Their catalytic activity was checked in the enantioselective Friedel–Crafts alkylation of indoles… read more here.
Keywords: crafts alkylation; alkylation indoles; asymmetric friedel; indoles catalyzed ... See more keywords