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Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c04149
Abstract: A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5–C-8 positions…
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Keywords:
activating group;
group free;
alkylation;
metal activating ... See more keywords