Microwave‐Promoted Metal‐Free α‐Alkylation of Ketones with Cycloalkanes through Cross‐Coupling of C(sp3)−H Bonds
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700256
Abstract: A MWI-promoted α-alkylation of ketones by using cycloalkanes as the alkylating agents under metal-free conditions is presented. Mechanistically, this alkylation involves a TBP-initiated and MWI-assisted formation of the required cycloalkyl radical and the α-ketone carbon… read more here.
Keywords: coupling sp3; sp3 bonds; alkylation; metal free ... See more keywords
Alkylation of Ketones Catalyzed by Bifunctional Iron Complexes: From Mechanistic Understanding to Application
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DOI: 10.1002/cctc.201701241
Abstract: Cyclopentadienone iron dicarbonyl complexes were applied in the alkylation of ketones with various aliphatic and aromatic ketones and alcohols via the borrowing hydrogen strategy in mild reaction conditions. DFT calculations and experimental works highlight the… read more here.
Keywords: alkylation ketones; ketones catalyzed; catalyzed bifunctional; iron ... See more keywords
DFT study on selective autocatalyzed α-alkylation of ketones with alcohols
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DOI: 10.1016/j.jcat.2019.03.033
Abstract: Abstract Base-promoted transition-metal-free α -alkylation of ketones with alcohols is an efficient, practical, and green method for the formation of new C C bonds. Here, we present a DFT study on NaOH/KOH-promoted selective autocatalyzed α… read more here.
Keywords: alkylation ketones; dft study; ketones alcohols; selective autocatalyzed ... See more keywords
sFrom selective transfer hydrogenation to selective hydrogen auto-transfer process: An efficient method for the synthesis of alkenyl ketones via iridium-catalyzed α-alkylation of ketones with alkenyl alcohols
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DOI: 10.1016/j.jcat.2021.08.038
Abstract: Abstract A strategy for the synthesis of alkenyl alcohols via the α-alkylation of ketones with alkenyl alcohols has proposed and accomplished. In the presence of a metal-ligand bifunctional catalyst [Cp*Ir(2,2’-bpyO)(H2O)], a series of desirable products… read more here.
Keywords: alkylation ketones; selective transfer; transfer; alkenyl alcohols ... See more keywords
Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols
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DOI: 10.1021/acscatal.8b03720
Abstract: Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are… read more here.
Keywords: manganese catalyzed; catalyzed alkylation; esters amides; alkylation ... See more keywords
Ruthenium Complexes Bearing α-Diimine Ligands and Their Catalytic Applications in N-Alkylation of Amines, α-Alkylation of Ketones, and β-Alkylation of Secondary Alcohols
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DOI: 10.1021/acsomega.2c03200
Abstract: New Ru(II) complexes encompassing α-diimine ligands were synthesized by reacting ruthenium precursors with α-diimine hydrazones. The new ligands and Ru(II) complexes were analyzed by analytical and various spectroscopic methods. The molecular structures of L1 and… read more here.
Keywords: diimine ligands; ruthenium complexes; amines alkylation; alkylation ... See more keywords
Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b03530
Abstract: We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the… read more here.
Keywords: ketones aldehydes; alkylation; catalyzed redox; redox cascade ... See more keywords