Mild C(sp3)‒H Alkylation of 8-Methylquinolines with α,β-Unsaturated Carbonyl Compounds by Rhodium(III) Catalysis
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DOI: 10.1002/ajoc.201700261
Abstract: A straightforward approach to the synthesis of γ-quinolyl carbonyl compounds has been presented via rhodium(III)-catalyzed C(sp3)-H alkylation of 8-methyquinolines with conjugated C＝C multiple bonds. Remarkably, this C(sp3)-H functionalization proceeds under mild reaction conditions, obviates the… read more here.
Keywords: alkylation methylquinolines; carbonyl compounds; sp3 alkylation; mild sp3 ... See more keywords
Rh(III)-Catalyzed Alkylation of 8-Methylquinolines with Oxabenzonorbornadienes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00652
Abstract: Herein, a concise Rh(III)-catalyzed C(sp3)-H alkylation of 8-methylquinolines with oxabenzonorbornadiene scaffolds and other strained olefins has been disclosed. The retention of the oxabenzonorbornadiene skeleton, broad substrate scope, and wide-ranging functional group tolerance are the key… read more here.
Keywords: methodology; catalyzed alkylation; alkylation; alkylation methylquinolines ... See more keywords