Asymmetric C-Alkylation of Nitroalkanes via Enzymatic Photoredox Catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12197
Abstract: Tertiary nitroalkanes and the corresponding α-tertiary amines represent important motifs in bioactive molecules and natural products. The C-alkylation of secondary nitroalkanes with electrophiles is a straightforward strategy for constructing tertiary nitroalkanes; however, controlling the stereoselectivity… read more here.
Keywords: asymmetric alkylation; alkylation nitroalkanes; alkylation; nitroalkanes via ... See more keywords
Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b04175
Abstract: A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched β-nitroamides from readily available α-bromoamides using mild reaction conditions that are compatible with… read more here.
Keywords: catalyzed asymmetric; asymmetric alkylation; enantioenriched nitroamides; nickel catalyzed ... See more keywords