C2-selective alkylation of pyridines by rhodium–aluminum complexes
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132339
Abstract: Abstract A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh–Al catalyst is reported. The use of aliphatic alkenes exclusively affords the linear alkylation products, while… read more here.
Keywords: alkylation pyridines; rhodium aluminum; selective alkylation; alkylation ... See more keywords
C-4 Regioselective Alkylation of Pyridines Driven by Mechanochemically Activated Magnesium Metal.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00684
Abstract: Mechanochemically activated magnesium(0) metal as a highly active mediator driving direct C-4-H alkylation of pyridines with alkyl halides has been developed. Excellent regioselectivity and substrate scope, including those containing reducible functionalities, free amines, and alcohols,… read more here.
Keywords: activated magnesium; magnesium metal; alkylation pyridines; mechanochemically activated ... See more keywords