Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides.
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DOI: 10.1021/acs.orglett.0c01277
Abstract: A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for… read more here.
Keywords: alkyl carboxylic; catalyzed selective; carboxylic acids; alkylation pyridones ... See more keywords
Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones.
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DOI: 10.1039/d1cc06110k
Abstract: A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role. read more here.
Keywords: regioselective alkylation; coordination effect; alkylation pyridones; palladium ... See more keywords
Regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion.
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DOI: 10.1039/d2cc05676c
Abstract: Selective alkylation of 2-pyridone could solve a challenge in chemistry and streamline the synthesis of important molecules. Here we report the regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion. In the catalytic system, alkylation of… read more here.
Keywords: catalyzed carbenoid; tfoh catalyzed; alkylation pyridones; alkylation ... See more keywords