Molecular Oxygen-Mediated Radical Alkylation of C(sp3)-H Bonds with Boronic Acids.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00948
Abstract: A direct and site-specific alkylation of (sp3)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinates and amines together with alkylboronic acids under an oxygen atmosphere, a variety of unnatural α-amino acids and… read more here.
Keywords: alkylation; molecular oxygen; alkylation sp3; oxygen mediated ... See more keywords
Nickel-catalysed alkylation of C(sp3)-H bonds with alcohols: direct access to functionalised N-heteroaromatics.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc06370b
Abstract: The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies have established the… read more here.
Keywords: catalysed alkylation; sp3; nickel catalysed; alkylation sp3 ... See more keywords