O4‐Alkylated‐2‐Deoxyuridine Repair by O6‐Alkylguanine DNA Alkyltransferase is Augmented by a C5‐Fluorine Modification
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DOI: 10.1002/cbic.201700660
Abstract: Oligonucleotides containing various adducts, including ethyl, benzyl, 4‐hydroxybutyl and 7‐hydroxyheptyl groups, at the O4 atom of 5‐fluoro‐O4‐alkyl‐2′‐deoxyuridine were prepared by solid‐phase synthesis. UV thermal denaturation studies demonstrated that these modifications destabilised the duplex by approximately… read more here.
Keywords: dna alkyltransferase; fluorine modification; dna; alkylguanine dna ... See more keywords
O6-alkylguanine-DNA Alkyltransferases in Microbes Living on the Edge: From Stability to Applicability
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DOI: 10.3390/ijms21082878
Abstract: The genome of living cells is continuously exposed to endogenous and exogenous attacks, and this is particularly amplified at high temperatures. Alkylating agents cause DNA damage, leading to mutations and cell death; for this reason,… read more here.
Keywords: dna; alkyltransferases microbes; dna alkyltransferases; microbes living ... See more keywords