Base-Promoted Chemodivergent Construction of 2H-Chromen-2-one and Chromeno[2,3-c]pyrrole Scaffolds from para-Quinone Methides and α-Alkylidene Succinimides.
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DOI: 10.1021/acs.orglett.4c03436
Abstract: Herein, we evolve a base-promoted synthesis of 2H-chromen-2-one and chromeno[2,3-c]pyrrole scaffolds via (4 + 2) annulation of α-alkylidene succinimides with 2-hydroxyphenyl-substituted para-quinone methides (p-QMs). Extremely selective and switchable cyclizations were obtained by modifying the base.… read more here.
Keywords: one chromeno; alkylidene succinimides; pyrrole scaffolds; base promoted ... See more keywords
(4+3) annulation of enone-tethered indoles with α-alkylidene succinimides: access to seven-membered azepino[3,2,1-hi]indole scaffolds
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DOI: 10.1039/d5cc02885j
Abstract: A (4+3) annulation of indole-enones and alkylidene succinimides for diastereoselective synthesis of seven-membered azepino[3,2,1-hi]indole scaffolds with four contiguous chiral carbons is reported. read more here.
Keywords: azepino indole; seven membered; alkylidene succinimides; indole scaffolds ... See more keywords