Deaminative Reductive Methylation of Alkylpyridinium Salts.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02458
Abstract: Methyl groups can imbue valuable properties in organic molecules, often leading to enhanced bioactivity. To enable efficient installation of methyl groups on simple building blocks and in late-stage functionalization, a nickel-catalyzed reductive coupling of secondary… read more here.
Keywords: alkylpyridinium; alkylpyridinium salts; reductive methylation; deaminative reductive ... See more keywords
Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01014
Abstract: A nickel-catalyzed reductive cross-coupling of alkylpyridinium salts and aryl bromides has been developed using Mn as the reductant. Both primary and secondary alkylpyridinium salts can be used, and high functional group and heterocycle tolerance is… read more here.
Keywords: aryl bromides; reductive cross; alkylpyridinium; alkylpyridinium salts ... See more keywords