Enantioselective Nickel-Catalyzed Reductive anti-Arylative Annulation of Alkyne-Tethered Malononitriles to Construct Quaternary Stereocenters.
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DOI: 10.1021/acs.orglett.3c00123
Abstract: A nickel-catalyzed reductive desymmetrizing annulation of alkyne-tethered malononitriles and (hetero)aryl iodides is reported for the access of cyclohexenones containing an α-all-carbon quaternary stereocenter. The use of a nickel catalyst derived from an electron-rich phosphinooxazoline ligand… read more here.
Keywords: tethered malononitriles; annulation alkyne; nickel catalyzed; catalyzed reductive ... See more keywords
Rhodium-Catalyzed Highly Regio- and Enantioselective Reductive Cyclization of Alkyne-Tethered Cyclohexadienones
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DOI: 10.1021/acscatal.7b04054
Abstract: Rhodium-catalyzed asymmetric hydrogenation of alkyne-tethered cyclohexadienones enables highly regio- and enantioselective reductive cyclization to afford cis-hydrobenzofurans and cis-hydroindoles in high yields. Desymmetrization of 1,3-diyne-tethered cyclohexadienones was also explored, wherein the intramolecular coordination of a Rh… read more here.
Keywords: rhodium catalyzed; reductive cyclization; alkyne tethered; highly regio ... See more keywords