Copper-Catalyzed Radical Addition of Alkynols to Synthesize Difluoroheterocyclic Compounds.
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DOI: 10.1021/acs.orglett.3c00968
Abstract: A convenient method for the synthesis of fluorine-containing heterocyclic compounds was developed by a copper-catalyzed free radical addition reaction of alkynol and ethyl bromodifluoroacetate. This strategy involves copper-catalyzed free radical addition and molecular lactone exchange… read more here.
Keywords: addition alkynols; catalyzed radical; alkynols synthesize; radical addition ... See more keywords