Visible-Light-Driven α-Aminoalkyl Radical-Mediated C(sp3)-C(sp) Cross-Coupling of Iodoalkanes and Alkynyl Bromides.
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DOI: 10.1021/acs.orglett.2c02018
Abstract: We herein report a simple protocol for metal-free cross-coupling between unactivated alkyl iodides and terminal alkynyl bromides promoted by visible light. The salient features of this transformation are the utilization of an organic photocatalyst and… read more here.
Keywords: driven aminoalkyl; cross coupling; alkynyl bromides; visible light ... See more keywords
Palladium-Catalyzed 1,1-Alkynyloxygenation of 2-Vinylbenzoates with Alkynyl Bromides.
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DOI: 10.1021/acs.orglett.3c01008
Abstract: The palladium-catalyzed reaction of alkyl 2-vinylbenzoates with silyl-protected alkynyl bromides leads to the selective production of 3-alkynylated isochroman-1-ones. The use of an alkyl ester group as an effective oxygen nucleophile is crucial for the efficient… read more here.
Keywords: vinylbenzoates alkynyl; palladium catalyzed; alkynyloxygenation vinylbenzoates; alkynyl bromides ... See more keywords
Nickel-Catalyzed Difunctionalization of Alkynyl Bromides with Thiosulfonates and N-Arylthio Succinimides: A Convenient Synthesis of 1,2-Thiosulfonylethenes and 1,1-Dithioethenes
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DOI: 10.1055/a-1482-2486
Abstract: An efficient Ni-catalyzed vicinal thiosulfonylation of 1-bromoalkynes with thiosulfonates in the presence of cesium carbonate has been described. An operationally simple and highly regioselective atom transfer radical addition (ATRA) of alkynyl bromides provided a wide… read more here.
Keywords: thiosulfonylation; synthesis; bromides thiosulfonates; alkynyl ... See more keywords