N-Heterocyclic Carbene-Catalyzed Synthesis of Ynones via C–H Alkynylation of Aldehydes with Alkynyliodonium Salts—Evidence for Alkynyl Transfer via Direct Substitution at Acetylenic Carbon
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DOI: 10.1021/acscatal.9b04394
Abstract: Alkynylation of aldehydes with alkynyl(aryl)iodonium salts catalyzed by an N-heterocyclic carbene (NHC) has been developed. The application of the organocatalyst and the hypervalent iodine group transfer reagent allowed for metal-free C–H functionalization and C–C bond… read more here.
Keywords: direct substitution; alkynylation aldehydes; substitution acetylenic; alkynyl transfer ... See more keywords