Copper-Catalyzed Cyclization of 2-Alkynylanilines to Give 2-Haloalkoxy-3-alkyl(aryl)quinolines.
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DOI: 10.1021/acs.orglett.2c04314
Abstract: Herein we describe a method to produce 2-haloalkoxy-3-substituted quinolines via the cyclization of 2-alkynylanilines with TMSCF3 and THF. This synthetic method uses inexpensive and easy-to-handle TMSCF3 and employs a commercially available CuI catalyst to transform… read more here.
Keywords: catalyzed cyclization; alkynylanilines give; cyclization; cyclization alkynylanilines ... See more keywords