N-Heterocyclic Carbene-Catalyzed Synthesis of Ynones via C–H Alkynylation of Aldehydes with Alkynyliodonium Salts—Evidence for Alkynyl Transfer via Direct Substitution at Acetylenic Carbon
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DOI: 10.1021/acscatal.9b04394
Abstract: Alkynylation of aldehydes with alkynyl(aryl)iodonium salts catalyzed by an N-heterocyclic carbene (NHC) has been developed. The application of the organocatalyst and the hypervalent iodine group transfer reagent allowed for metal-free C–H functionalization and C–C bond… read more here.
Keywords: direct substitution; alkynylation aldehydes; substitution acetylenic; alkynyl transfer ... See more keywords
Practical Synthesis of α,β-Alkynyl Ketones by Oxidative Alkynylation of Aldehydes with Hypervalent Alkynyliodine Reagents
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry Letters"
DOI: 10.1246/cl.200131
Abstract: A practical, metal-free carbonyl C(sp2)–H oxidative alkynylation of aldehydes with hypervalent alkynyliodine reagents without the use of any catalysts is described for the synthesis of various α,β-... read more here.
Keywords: alkynylation aldehydes; aldehydes hypervalent; oxidative alkynylation; alkynyliodine reagents ... See more keywords