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Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00041h
Abstract: Cu/(Ph-pybox)-catalyzed asymmetric dearomative alkynylation of isoquinolines has been realized in high to excellent enantioselectivities (up to 96% ee) with α-bromoacetophenone as an activator and 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate as an additive. This novel reaction tolerates a wide…
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Keywords:
dearomative alkynylation;
catalyzed asymmetric;
alkynylation isoquinolines;
asymmetric dearomative ... See more keywords