Alkynyloxy derivatives of 5,8-quinolinedione: Synthesis, in vitro cytotoxicity studies and computational molecular modeling with NAD(P)H:Quinone oxidoreductase 1.
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DOI: 10.1016/j.ejmech.2016.12.031
Abstract: The natural 7-amino-5,8-quinolinodione antibiotics were the substrate for the NQO1 protein. The structure-activity relationship showed that the 5,8-quinolinedione moiety was responsible for the interaction with the enzyme. In our research, we presented the synthesis, cytotoxic… read more here.
Keywords: nqo1 protein; quinone oxidoreductase; nad quinone; alkynyloxy derivatives ... See more keywords