Thromboses and hemorrhages are common in MPN patients with high JAK2V617F allele burden
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-3040-8
Abstract: The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance… read more here.
Keywords: jak2v617f allele; allele burden; mpn patients;
High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-01-828467
Abstract: Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 World Health Organization classification and is associated with a favorable prognosis. Although previous studies have evaluated NPM1 in… read more here.
Keywords: high npm1; novo aml; mutant allele; allele burden ... See more keywords
Low JAK2 V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional CALR or MPL Gene Mutations
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DOI: 10.3390/genes12040559
Abstract: JAK2 (Janus kinase 2) V617F, CALR (Calreticulin) exon 9, and MPL (receptor for thrombopoietin) exon 10 mutations are associated with the vast majority of Ph-negative chronic myeloproliferative neoplasms (MPNs). These mutations affect sequential stages of… read more here.
Keywords: v617f allele; jak2 v617f; calr; allele burden ... See more keywords