Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0568-7
Abstract: BackgroundEthnic variability in the pharmacokinetics of organic anion transporting polypeptide (OATP) 1B1 substrates has been observed, but its basis is unclear. A previous study hypothesizes that, without applying an intrinsic ethnic variability in transporter activity,… read more here.
Keywords: ethnic variability; allele frequencies; variability transporter; variability ... See more keywords
Single step strategy for estimating unknown STR allele frequencies in a population
Sign Up to like & getrecommendations! Published in 2019 at "Forensic Science International: Genetics Supplement Series"
DOI: 10.1016/j.fsigss.2019.10.155
Abstract: Abstract Constant growth of forensic DNA databases requires new STR markers to be developed, tested and validated. Aiming to simplify the process of obtaining allele frequency distributions of new STR loci included in new megaplexes,… read more here.
Keywords: single step; allele frequencies; allele frequency; dna ... See more keywords
The first data of allele frequencies for 23 autosomal STRs in the Ede ethnic group in Vietnam.
Sign Up to like & getrecommendations! Published in 2022 at "Legal medicine"
DOI: 10.1016/j.legalmed.2022.102072
Abstract: Settled in Vietnam, the Ede ethnic group exhibits unique heritages that belong to the Austronesian-speaking groups. In this study, we genotyped 23 autosomal short tandem repeat (STR) markers in 397 unrelated samples from the Ede… read more here.
Keywords: data allele; ethnic group; 999 999; first data ... See more keywords
Elevated Leukodystrophy Incidence Predicted From Genomics Databases.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2020.06.005
Abstract: BACKGROUND Leukodystrophies are genetic diseases affecting the white matter and leading to early death. Our objective was to determine leukodystrophy incidence, using genomics sequencing databases allele frequencies of disease-causing variants. METHODS From 49 genes, representing… read more here.
Keywords: incidence; allele frequencies; leukodystrophy; incidence predicted ... See more keywords
Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3877
Abstract: Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures read more here.
Keywords: allele frequencies; tumor allele; limit power; reply uncertainties ... See more keywords
Strategies and cost–benefit of selecting for a polled sheep nucleus by using DNA testing
Sign Up to like & getrecommendations! Published in 2019 at "Animal Production Science"
DOI: 10.1071/an17720
Abstract: The present study assessed the effectiveness and cost–benefit of several genotyping strategies for breeding poll Merino sheep in a closed nucleus with different initial allele frequencies and assuming a single-gene responsible for the horn or… read more here.
Keywords: cost benefit; allele frequencies; genetic gain; starting allele ... See more keywords
Analysis of allele frequencies of 15 STR loci in a large population dataset from Ukraine at the regional level
Sign Up to like & getrecommendations! Published in 2020 at "Australian Journal of Forensic Sciences"
DOI: 10.1080/00450618.2020.1749930
Abstract: ABSTRACT We aimed to improve the reference allele frequency database for Ukraine and to investigate whether any population genetic structure can be detected at the local regional level. The AmpFlSTR®Identifiler®Plus kit was used to genotype… read more here.
Keywords: allele frequencies; regional level; level; dataset ... See more keywords
Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2021.0204
Abstract: Background: Few studies have estimated African ancestry of African Americans (AA). In sub-Saharan West African (WA) Blacks, some nonancestral alleles of iron-related genes HJV, SLC40A1, and TFR2 are common, whereas in European Americans (EA) the… read more here.
Keywords: ancestry; hjv slc40a1; allele frequencies; slc40a1 tfr2 ... See more keywords
PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty536
Abstract: Summary: Next‐generation sequencing (NGS) generates large amounts of genomic data and reveals about 20 000 genetic coding variants per individual studied. Several mutation damage prediction scores are available to prioritize variants, but there is currently… read more here.
Keywords: minor allele; allele frequencies; prediction scores; damage prediction ... See more keywords
A Maximum-Likelihood Approach to Estimating the Insertion Frequencies of Transposable Elements from Population Sequencing Data
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msy152
Abstract: Abstract Transposable elements (TEs) contribute to a large fraction of the expansion of many eukaryotic genomes due to the capability of TEs duplicating themselves through transposition. A first step to understanding the roles of TEs… read more here.
Keywords: sequencing data; allele frequencies; insertion; maximum likelihood ... See more keywords
Nuclear eDNA estimates population allele frequencies and abundance in experimental mesocosms and field samples
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Ecology"
DOI: 10.1111/mec.15765
Abstract: Advances in environmental DNA (eDNA) methodologies have led to improvements in the ability to detect species and communities in aquatic environments, yet the majority of studies emphasize biological diversity at the species level by targeting… read more here.
Keywords: allele frequencies; field samples; experimental mesocosms; mesocosms field ... See more keywords