Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer.
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DOI: 10.1016/j.ccell.2018.10.003
Abstract: Driver mutations in oncogenes encode proteins with gain-of-function properties that enhance fitness. Heterozygous mutations are thus viewed as sufficient for tumorigenesis. We describe widespread oncogenic mutant allele imbalance in 13,448 prospectively characterized cancers. Imbalance was… read more here.
Keywords: imbalance; selection; allele imbalance; mutant allele ... See more keywords