Late steps of allelic break-induced replication suppress tandem duplication associated with BRCA1 deficiency
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DOI: 10.1093/nar/gkaf729
Abstract: Abstract Microhomology-mediated tandem duplication (TD) is a distinct mutational signature in BRCA1-deficient tumors. While several mechanisms have been proposed for its generation, much understanding comes from repeat-based reporters, which may not represent the region of… read more here.
Keywords: induced replication; allelic break; brca1 deficient; tandem duplication ... See more keywords