Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain
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DOI: 10.1016/j.neuron.2017.01.033
Abstract: Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and… read more here.
Keywords: effects shape; non genetic; allelic effects; diverse non ... See more keywords
The emerging landscape of in vitro and in vivo epigenetic allelic effects
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DOI: 10.12688/f1000research.11491.1
Abstract: Epigenetic mechanisms that cause maternally and paternally inherited alleles to be expressed differently in offspring have the potential to radically change our understanding of the mechanisms that shape disease susceptibility, phenotypic variation, cell fate, and… read more here.
Keywords: vivo epigenetic; vitro vivo; emerging landscape; allelic effects ... See more keywords
How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects
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DOI: 10.1371/journal.pgen.1007075
Abstract: For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the… read more here.
Keywords: expressivity; ordering allelic; genetic background; effects genetic ... See more keywords