Global discovery of lupus genetic risk variant allelic enhancer activity
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DOI: 10.1038/s41467-021-21854-5
Abstract: Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we construct a massively parallel reporter assay (MPRA) library… read more here.
Keywords: allelic enhancer; risk loci; enhancer activity; risk ... See more keywords