KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.01.020
Abstract: Investigating therapeutic "outliers" that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in KrasG12D "knockin"… read more here.
Keywords: cancer; map kinase; allelic imbalance; fitness ... See more keywords
Replicate sequencing libraries are important for quantification of allelic imbalance
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23544-8
Abstract: A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and sequence only… read more here.
Keywords: allelic imbalance; analysis; rna seq; rna ... See more keywords
Abstract 3649: Allelic imbalance inKMT2A-rearranged infant acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3649
Abstract: Background Infant acute lymphoblastic leukemia (ALL) is a malignant disorder with poor clinical outcome. It is well-known that infant ALL cases with rearrangement of the KMT2A gene (KMT2A-r) have an even poorer prognosis than non-KMT2A-r… read more here.
Keywords: imbalance; kmt2a cases; infant acute; lymphoblastic leukemia ... See more keywords
Power calculator for detecting allelic imbalance using hierarchical Bayesian model
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DOI: 10.1186/s13104-021-05851-x
Abstract: Objective Allelic imbalance (AI) is the differential expression of the two alleles in a diploid. AI can vary between tissues, treatments, and environments. Methods for testing AI exist, but methods are needed to estimate type… read more here.
Keywords: calculator detecting; allelic imbalance; power calculator; power ... See more keywords
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
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DOI: 10.1371/journal.pcbi.1008772
Abstract: Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic and allele-biased expression observed… read more here.
Keywords: monoallelic expression; transcriptional bursting; transcriptional bursts; expression ... See more keywords
STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72837
Abstract: Mapping of allelic imbalance (AI) at heterozygous loci has the potential to establish links between genetic risk for disease and biological function. Leveraging multi-omics data for AI analysis and functional annotation, we discovered a novel… read more here.
Keywords: variant rs1047643; cell; association systemic; allelic imbalance ... See more keywords