Towards a more predictable plant breeding pipeline with CRISPR/Cas-induced allelic series to optimize quantitative and qualitative traits.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2018.04.013
Abstract: The rate of crop improvement must increase to meet rising global demand for food. Crop breeding pipelines can be hampered by the imprecision and multi-generational timeframe of methods such as intercrossing and stochastic mutagenesis used… read more here.
Keywords: qualitative traits; plant breeding; allelic series; breeding ... See more keywords
Abstract PR06: An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-pr06
Abstract: KRAS is the most frequently mutated oncogene in cancer. Tumor sequencing has revealed a complex spectrum of KRAS mutations across different cancer types, yet there is little understanding of how specific KRAS alterations impact tumor… read more here.
Keywords: series reveals; vivo kras; cancer; kras allelic ... See more keywords
Inferring the Allelic Series at QTL in Multiparental Populations.
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303393
Abstract: Multiparent populations are experimental populations generated by breeding together a genetically diverse set of inbred founder strains to produce individuals whose genomes are random mosaics of the founder haplotypes..... read more here.
Keywords: multiparental populations; inferring allelic; series qtl; qtl multiparental ... See more keywords