Palladium-Catalyzed Stereoselective Cyclization of in Situ Formed Allenyl Hemiacetals: Synthesis of Rosuvastatin and Pitavastatin.
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DOI: 10.1021/acs.orglett.8b01156
Abstract: A diastereoselective palladium-catalyzed cyclization of allenyl hemiacetals is described. It permits the selective synthesis of 1,3-dioxane derivatives, precursors for syn-configured 1,3-diols which make an appearance in all of the statin representatives. The reaction allows the… read more here.
Keywords: synthesis rosuvastatin; cyclization; palladium catalyzed; rosuvastatin pitavastatin ... See more keywords