Efficient and stereoselective synthesis of (S)-α-propargylglycine derivatives from allenylboronic acid
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DOI: 10.1016/j.mencom.2019.09.006
Abstract: The Petasis–Mannich reaction of allenylboronic acid with glyoxylic acid and (S)-1-phenylethylamine diastereoselectively leads to N-substituted propargylglycine of high optical purity in good yield. This product can be further subjected to esterification followed by bioconjugate synthesis… read more here.
Keywords: allenylboronic acid; propargylglycine; stereoselective synthesis; synthesis propargylglycine ... See more keywords