Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00874-x
Abstract: Previous studies demonstrated that the endogenous neurosteroid allopregnanolone (Allo) promotes regeneration of rodent and human neural progenitor/neural stem cells (NSCs) in vitro and in vivo, and restores neurogenesis and cognitive function in the male triple… read more here.
Keywords: oligodendrocyte differentiation; vitro vivo; alzheimer disease; allo ... See more keywords
Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.04.007
Abstract: The development of T cell tolerance in the thymus requires the presentation of host proteins by multiple antigen-presenting cell (APC) types. However, the importance of transferring host antigens from transcription factor AIRE-dependent medullary thymic epithelial cells… read more here.
Keywords: tolerance; allo; cd36; receptor ... See more keywords
Altered glucocorticoid metabolism in girls with central obesity
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111225
Abstract: BACKGROUND Dysregulation of glucocorticoid metabolism is known to be a causative factor of obesity. However, only a few studies have evaluated the enzymatic activities involved in glucocorticoid metabolism in the pediatric population. OBJECTIVE To examine… read more here.
Keywords: obesity; allo thf; allo; glucocorticoid metabolism ... See more keywords
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2132903
Abstract: The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids, which are responsible for intestinal lipid digestion and function as key nutrient-signaling molecules. The human liver produces bile acids from cholesterol predominantly… read more here.
Keywords: bile acids; bile acid; allo; allo lca ... See more keywords
Deciding between Multiple Curative Options in Sickle Cell Disease: Cost-Effectiveness of Non-Myeloablative/Reduced Intensity Conditioning Haploidentical Allo-HSCT Vs Gene Therapy Vs Standard of Care in Adult Patients with Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-203234
Abstract: Introduction: The recent approval and high prices of curative gene therapy for sickle cell disease (SCD), a disease known to substantially decrease quality of life, has also invigorated efforts within the allotransplantation (allo-HSCT) space. As… read more here.
Keywords: disease; hid; allo hsct; allo ... See more keywords
Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02363-3
Abstract: Background We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and inflammaging.… read more here.
Keywords: anti viral; allo; allo priming; th1 ctl ... See more keywords
Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006024
Abstract: Snakebites have been recognized as a neglected public health problem in several tropical and subtropical countries. Bothrops snakebites frequently complicate with acute kidney injury (AKI) with relevant morbidity and mortality. To date, the only treatment… read more here.
Keywords: kidney injury; allo; acute kidney; bothrops jararaca ... See more keywords
Production of Cytotoxic Antibodies After Intra-Articular Injection of Allogeneic Synovial Membrane Mesenchymal Stem Cells With and Without LPS Administration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.871216
Abstract: Allogeneic mesenchymal stem cells (MSC) are widely used in clinical routine due to the shorter expansion time and reliability of its quality. However, some recipients can produce alloantibodies that recognize MSCs and activate the immune… read more here.
Keywords: injection; intra articular; production; allo ... See more keywords
Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2024.1499416
Abstract: Background Allopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes. Studies suggest a U-shaped… read more here.
Keywords: peripartum mood; peripartum; mood peripartum; risk ... See more keywords