The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors
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DOI: 10.3390/biom13020341
Abstract: The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not. This study was… read more here.
Keywords: ent allo; allo preg; gabaa receptors; ent ... See more keywords