Bone marrow‐derived mesenchymal stem cells alleviate paclitaxel‐induced mechanical allodynia in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23207
Abstract: Anticancer drug paclitaxel (PTX) frequently causes painful peripheral neuropathy; however, no medication has been shown to be effective in the treatment of this debilitating side effect. We aimed to investigate the efficacy of two different… read more here.
Keywords: ptx; induced mechanical; bone marrow; allodynia ... See more keywords
Metabotropic glutamate receptor 5‐mediated inhibition of inward‐rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25181
Abstract: Inward‐rectifying K+ channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K+ homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) regulates the expression of Kir4.1… read more here.
Keywords: orofacial ectopic; allodynia; mechanical allodynia; ectopic mechanical ... See more keywords
Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.03.011
Abstract: Facial allodynia is a migraine symptom that is generally considered to represent a pivotal point in migraine progression. Treatment before development of facial allodynia tends to be more successful than treatment afterwards. As such, understanding… read more here.
Keywords: supradural inflammatory; allodynia; facial allodynia; inflammatory soup ... See more keywords
The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119308
Abstract: AIMS Brain-derived neurotrophic factor (BDNF) is vital in the pathogenesis of mechanical allodynia with a paucity of reports available regarding diabetic neuropathy pain (DNP). Herein we identified the involvement of BDNF in driving mechanical allodynia… read more here.
Keywords: dnp rats; allodynia; mechanical allodynia; bdnf induced ... See more keywords
Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.03.022
Abstract: The growing presence of artificial lighting across the globe presents a number of challenges to human and ecological health despite its societal benefits. Exposure to artificial light at night, a seemingly innocuous aspect of modern… read more here.
Keywords: night; dim light; light night; hyperalgesia mechanical ... See more keywords
Treadmill workouts alleviate neuropathic allodynia and scratching behavior in rats following thoracotomy
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2021.2024719
Abstract: ABSTRACT Background The aim of the experiment was to investigate the effects of treadmill exercise on postthoracotomy pain and the expression of spinal pro-inflammatory and anti-inflammatory cytokines. Methods Animals were randomly distributed into four groups:… read more here.
Keywords: rats following; thoracotomy; treadmill; allodynia ... See more keywords
Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2018 at "PAIN"
DOI: 10.1097/j.pain.0000000000001160
Abstract: Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer treatment that significantly compromises quality of life of cancer patients and survivors. Identification of targets for pharmacological intervention to prevent or reverse CIPN… read more here.
Keywords: paclitaxel induced; nerve; allodynia; mechanical allodynia ... See more keywords
Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001667
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse side effect of cancer treatment with no FDA-approved medication for its prevention or management. Using RNA sequencing analysis of dorsal root ganglia (DRG) we identify critical contributions… read more here.
Keywords: induced mechanical; cisplatin induced; allodynia; mechanical allodynia ... See more keywords
Anti-allodynic effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic migrainein rodents
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14462
Abstract: Background and purpose: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential therapeutic targets in pain of the orofacial region. Amiloride, a non‐specific ASIC blocker, has been shown to exert beneficial effects in… read more here.
Keywords: sensing ion; effects systemic; ion channels; acute chronic ... See more keywords
PTH-124 Centrally mediated disorders, abdominal allodynia and neuropathic pain: the first cohort-specific evaluation of rome iv criteria
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2017-314472.523
Abstract: Introduction Centrally mediated disorders (chronic abdominal pain syndrome (CAPS) and narcotic bowel syndrome (NBS)) have been redefined by Rome IV1. We aimed to compare Rome IV and neuropathic pain (NP)2 criteria performance in a disease… read more here.
Keywords: rome; centrally mediated; mediated disorders; abdominal allodynia ... See more keywords
Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression
Sign Up to like & getrecommendations! Published in 2018 at "Cephalalgia"
DOI: 10.1177/0333102417714032
Abstract: Background A subgroup of migraineurs experience an increase in attack frequency leading to chronic migraine. Methods We assessed in rats the roles of dose and repeat administration of systemic isosorbide dinitrate (ISDN), a nitric oxide… read more here.
Keywords: administration; isdn; allodynia; nitric oxide ... See more keywords