CRIPSR/Cas9 Technology: Hypoimmunogenic Pluripotent Stem Cells Evade Immune Rejection in Fully Immunocompetent Allogeneic Recipients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1806
Abstract: Purpose Induced pluripotent stem cells (iPSCs) are promising candidates for regenerative medicine. To overcome the allogeneic immune barrier, we created hypo-immune iPSCs using CRISPR/Cas9 editing strategies and demonstrate long-term survival of allografts without the need… read more here.
Keywords: pluripotent stem; ipscs; cas9 technology; stem cells ... See more keywords
Outcome of allogeneic hematopoietic stem cell transplantation for follicular lymphoma relapsing after autologous transplantation: analysis of the Japan Society for Hematopoietic Cell Transplantation
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DOI: 10.1038/s41409-020-01192-8
Abstract: Autologous stem cell transplantation (SCT) is an effective treatment for patients with relapsed and refractory follicular lymphoma (FL), but more than half patients experience relapse [1, 2]. Despite high transplant-related mortality, allogeneic SCT could be… read more here.
Keywords: relapsing autologous; cell transplantation; hematopoietic cell; allogeneic ... See more keywords
Long-Term Hematopoietic Engraftment of Congenic Amniotic Fluid Stem Cells After in Utero Intraperitoneal Transplantation to Immune Competent Mice
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cells and Development"
DOI: 10.1089/scd.2017.0116
Abstract: Clinical success of in utero transplantation (IUT) using allogeneic hematopoietic stem cells (HSCs) has been limited to fetuses that lack an immune response to allogeneic cells due to severe immunological defects, and where transplanted genetically… read more here.
Keywords: engraftment; long term; allogeneic; amniotic fluid ... See more keywords
Bone Marrow Graft-Versus-Host Disease in Reduced Intensity Conditioned Major Histocompatibility Complex Matched Murine Allogeneic Hematopoietic Cell Transplantation
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DOI: 10.1097/01.tp.0000543199.79339.af
Abstract: Background The majority of clinical allogeneic haemopoietic cell transplants (alloHCT) are currently performed using reduced intensity conditioning (RIC) instead of myeloablative conditioning (MAC). However, most of the murine models for alloHCT and ensuing complications such… read more here.
Keywords: histocompatibility; mac; allogeneic; mice ... See more keywords
The Transient Display of a Chimeric PD-L1 Protein on Pancreatic Islets Promotes Indefinite Survival in Allogeneic Recipients
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DOI: 10.1097/01.tp.0000543248.46167.ff
Abstract: Introduction and Objective Allogenic islet transplantation is an important therapeutic approach for the treatment of Type 1 Diabetes (T1D). However, graft rejection initiated and perpetuated by pathogenic T effector (Teff) cells presents a major barrier.… read more here.
Keywords: protein; pdl1; treatment; allogeneic ... See more keywords
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia
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DOI: 10.1136/jitc-2022-005400
Abstract: Background Chimeric antigen receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory hematological tumors, showing impressive complete remission rates. However, around 50% of the patients relapse before 1-year post-treatment. T-cell ‘fitness’ is critical… read more here.
Keywords: proof concept; myeloid leukemia; car; acute myeloid ... See more keywords
In Vivo Immunogenic Response to Allogeneic Mesenchymal Stem Cells and the Role of Preactivated Mesenchymal Stem Cells Cotransplanted with Allogeneic Islets
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/9824698
Abstract: Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory… read more here.
Keywords: allogeneic; mscs; allogeneic islets; stem cells ... See more keywords
Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.
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DOI: 10.1158/0008-5472.can-21-2931
Abstract: CD70 is highly expressed in renal cell carcinoma (RCC), with limited expression in normal tissue, making it an attractive CAR T target for an immunogenic solid tumor indication. Here we generated and characterized a panel… read more here.
Keywords: renal cell; cd70; car; allogeneic ... See more keywords
[Allogeneic hematopoietic stem cell transplantation in Hungary].
Sign Up to like & getrecommendations! Published in 2017 at "Orvosi hetilap"
DOI: 10.1556/650.2017.30648
Abstract: INTRODUCTION AND AIM The publication summarizes the 2548 stem cell transplantations performed in the period of 1993-2015 in Szent Laszló Hospital, Budapest and provides a detailed discussion of the 425 allogeneic transplantations during 2007-2013. METHOD… read more here.
Keywords: stem cell; transplantation; cell transplantation; allogeneic ... See more keywords
Clinical Experience of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients Aged 60 Years and Older in South Korea
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DOI: 10.3349/ymj.2022.0331
Abstract: Purpose The purpose of this study is to share our outcomes and experiences on allogeneic hematopoietic stem cell transplantation (HSCT) in elderly patients aged 60 years and older with myelodysplastic syndrome (MDS) or acute myeloid… read more here.
Keywords: aged years; allogeneic; years older; cell transplantation ... See more keywords
MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation
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DOI: 10.3390/ijms22094895
Abstract: Mesenchymal stem cells (MSCs) have been widely used in therapeutic applications for many decades. However, more and more evidence suggests that factors such as the site of origin and pre-implantation treatment have a crucial impact… read more here.
Keywords: collagen type; allogeneic syngeneic; allogeneic; transplantation ... See more keywords