Loss of surface CD3 expression in allogeneic CAR T‐cells
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25775
Abstract: F IGURE 1 Allogeneic CAR T-cells in the clinical laboratory. A, B, Peripheral blood smear photomicrographs from patient 1 show CAR T cells in peripheral blood smear with ample cytoplasm and granules. C, Flow cytometry… read more here.
Keywords: surface cd3; allogeneic car; loss surface; car cells ... See more keywords
111 Highly efficient multiplexed base editing enables development of universal CD7-targeting CAR-T Cells to treat T-ALL
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0111
Abstract: Background Autologous CAR-T therapies have demonstrated remarkable efficacy in treating some hematologic cancers. However, generating bespoke cell therapies creates manufacturing challenges, inconsistent products, high cost of goods, and delays in treatment that are often incompatible… read more here.
Keywords: base editing; allogeneic car; base; cd7 ... See more keywords
Murine allogeneic CAR T cells integrated before or early after posttransplant cyclophosphamide exert antitumor effects
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DOI: 10.1182/blood.2022016660
Abstract: Key Points • Murine allogeneic anti-CD19 CAR T cells integrated before or early after PTCy for allo-HCT can clear leukemia without added toxicity.• Clinical translation of this approach would combine the activity of both CAR… read more here.
Keywords: integrated early; murine allogeneic; allogeneic car; car ... See more keywords
Allogeneic CAR T Cells: An Alternative to Overcome Challenges of CAR T Cell Therapy in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.640082
Abstract: Chimeric antigen receptor (CAR) T cell therapy has emerged as one of the major breakthroughs in cancer immunotherapy in the last decade. Outstanding results in hematological malignancies and encouraging pre-clinical anti-tumor activity against a wide… read more here.
Keywords: car cell; cell therapy; allogeneic car; car cells ... See more keywords